ABSTRACT
A lesao pulmonar surge em até 50-70 por cento dos pacientes com pancreatite aguda. A infusao de ceruleína em doses fisiológicas reduz o conteúdo enzimático do pâncreas com diminuiçao da taxa de mortalidade da pancreatite. Com objetivo de avaliar o efeito da reduçao do conteúdo enzimático do pâncreas sobre a lesao pulmonar da pancreatite aguda, foi induzida pancreatite em ratos Wistar através da infusao, dentro do ducto biliar, de soluçao de taurocolato de sódio a 5 por cento: grupo I, ratos com pancreatite; grupo II, ratos nos quais pancreatite foi induzida somente após reduçao do conteúdo enzimático do pâncreas, e grupo III, controle. A lesao pulmonar foi avaliada através da utilizaçao do corante azul de Evans, sendo menor no grupo II comparativamente ao I (P
Subject(s)
Rats , Animals , Male , Ceruletide/therapeutic use , Pancreas/drug effects , Pancreatitis/enzymology , Taurocholic Acid/pharmacology , Acute Disease , Analysis of Variance , Evans Blue , Pancreatitis/chemically induced , Pancreatitis/drug therapy , Pancreatitis/mortality , Rats, WistarABSTRACT
A previous report has show that cerulein in physiological doses reduces the rate mortality of pancreatitis by decreasing the enzyme content of the pancreas. Clinically detectable signs of lung injury develop in up to 50-70 percent of patients with acute pancreatitis. The aim of the present study was to assess the effect of acute reduction of pancreatic enzyme content on the pancreatitis pulmonary injury. Experimental haemorrhagic pancreatitis was induced by intraductal injection of 5 per cent sodium taurocholate in two groups of Wistar rats: group I (pancreatitis) and group II (pancreatitis after decreasing pancreatic enzyme content). Dye Evans blue was used to evaluate the lung injury. The degree of histologically observed lesions were similar in both groups, but the pulmonary lesion was smaller in group II than group I (p < 0.05). In conclusion: 1) pancreatitis' pulmonary lesion may be related with pancreatic enzymes that reach the blood stream and 2) the reduction of the pancreatic enzyme content has a beneficial effect on acute pancreatitis and reduces its pulmonary injury.